Description
Revolution Medicines, Inc. is a clinical-stage precision oncology company. The Company is focused on developing targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on the renin angiotensin system (RAS) and mammalian target of rapamycin (mTOR) signaling pathways.
The company’s research and development (R&D) pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. Its RAS(ON) Inhibitors in development include RMC-6236, RMC-6291, RMC-9805 and RMC-8839, and a pipeline of research compounds targeting additional RAS variants.
The RAS Companion Inhibitors in clinical development include RMC-4630 (SHP2) and RMC-5552 (mTORC1/4EBP1). The Company’s tri-complex technology enables to discover small molecule inhibitors of targets lacking intrinsic drug binding sites by inducing new druggable pockets.
